Current knowledge of chemokine biology should propel the field toward a better understanding of the contribution that chemokine dysregulation makes to chronic inflammation, excess or impaired angiogenesis, and, equally important but more challenging, their role in pathological wound healing. One can use modified antagonists of the proteins themselves or of their N-termini; use monoclonal antibodies directed either to a specific chemokine or to its receptor; and use small molecules that inhibit their receptors. Available information in preclinical and clinical settings suggests that the chemokine system represents a valuable target for the development of innovative therapeutic strategies.
Chemokines have potential as therapeutic agents in several ways
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